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Author Contributions Writingoriginal draft preparation, F.G.M

12 Figure 3: Overview of antioxidant pathways Schematic overview displaying the major pathways involved in the elimination of ROS, including reduced glutathione (GSH), thioredoxin (Trx), catalase, and the NRF2 transcription factor, as explained in the text

5 Heurteaux et al., Nature Neuroscience (2006)TREK-1 knockout produces a depression-resistant phenotype, establishing TREK-1 as an antidepressant target