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Compared to GLP-1 RA trials for weight loss in non-cancer populations who typically saw a 515% reduction in body weight, 6 the weight loss in this cohort was considered modest
For some researchers, the additional weight loss from higher doses is not worth the increased side effect burden, and a dose between 1.0 and 1.7 mg represents their personal optimal balance
Vision loss: NAION A 2024 study published in JAMA Ophthalmology found a significantly elevated risk of non-arteritic anterior ischemic optic neuropathy (NAION), a form of vision loss caused by reduced blood flow to the optic nerve, in people taking semaglutide
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