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909 In SPCA1, Mn II was found to bind to the same metal binding site II as Ca II , but more tightly in forming a lower coordination number square pyramidal complex that results in residues on TM6, in particular D742, moving closer to those ligands derived from TM4, which donates three main-chain carbonyl oxygens to the metal

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Cardiometabolic secondary endpoints, including measures such as waist circumference and blood pressure, were reported directionally in favor of the combination arm

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