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She explains that menopausal women often show an increase of antioxidant capacity as well as lower glutathione levels along with high levels of oxidative damage. According to Tennant, this rise in antioxidant capacity may be compensatorya protective response as the body ramps up defenses to counteract mounting oxidative stress.Since glutathione levels decrease while oxidative stress increases, its reasonable to consider supplementing with glutathione or NAC, alongside lifestyle interventions like exercise, diet, sleep, stress management, and possibly hormone replacement therapy, Tennant says

Feedback inhibition of methylene-tetrahydrofolate reductase in rat liver by S-adenosylmethionine

The peroxidation of the PUFA chains leads to the destruction of the phospholipid bilayer membrane structure of the cell enhancing membrane permeability, which ultimately leads to cell death [58, 59]

This can produce a functional undermethylation pattern without assuming that every patient simply needs more methyl donors