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A contextual relationship between whole-brain c-Fos activation and semaglutide was established by comparing the semaglutide-specific c-Fos heatmap (Figure 6B) with 2469 brain connectivity maps from the AIBS

This balanced distribution of baseline characteristics minimizes potential confounding factors and strengthens the validity of attributing any subsequent differences in outcomes to the interventions under investigation rather than to pre-existing differences

It has been demonstrated that these structural alterations exert complete resistance to GLP-1 cleavage caused by DPP-IV and trypsin degradation 52,53,54,55

Neuroprotective drugs such as edaravone, nerve growth factor, and neurotrophin protect the brain from oxidative stress and ferroptosis