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10.1002/ijc.28148 55 MaubachG.LimM

Beyond the aforementioned immune cells, ILC2s originating from other organs such as the kidney migrate to the small intestine, where they adapt to the local microenvironment via the retinoic acid signaling pathway and acquire small intestine-specific phenotypes and functions, playing a critical role in combating helminth infections ( e.g ., Strongyloides ratti).Although RNA velocity analysis of kidney-derived ILC2s migrating into the small intestine suggests a progressive shift from a kidney program toward a small intestine program in effector ILC2s, definitive confirmation of the adaptive capacity of progeny ILC2s requires additional validation at the single-cell clonal resolution (67)

Int J Mol Sci (2020) 21(17):6206

The spectrum after 5 min of treatment showed the same fragmentation pattern as the spectrum after 3 min