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Experiments to explore the substrate specificity at the terminal amino acid of all GS-like enzymes were carried out using 2.5 mM ATP and 1 mM -EC with the following amino acids at 100 mM: glycine, -alanine, D-alanine, GABA, AABA, diaminopropionic acid, D-serine)

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While many interventions for AD/ADRD have focused on midlife and late-life deficits, a precision brain health approach to AD/ADRD prevention should consider opportunities for personalized interventions implemented at earlier ages as part of a life-course approach to brain health optimization and resilience

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