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The STEP clinical trial program established semaglutide as a legitimate weight loss medication

doi: 10.3390/molecules25225474 [DOI] [PMC free article] [PubMed] [Google Scholar] 92

Despite their promise, the rapid rise in the use of GLP-1 agonists in a relatively short period of time has led to concern from both scientists and the public regarding the long-term safety and efficacy of these drugs

Although GLP-1 RAs do not affect warfarin pharmacokinetics, their appetite-reducing effects may decrease vitamin K intake and increase International Normalized Ratio (INR) variability