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The reduction in fatty acid levels appears to be the molecular signal leading to increased expression of NPY and AgRP

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and/or CBCL Emotionally Reactive T-Score, in a subject in need thereof having autism or ASD.In certain embodiments, the above methods and uses may include an initial step of identifying a subject in need of treatment based on the subject having impairment in one or more behavioural traits which are assessed by one or more of: CARS behaviour T-Score