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As H 2 O 2 and superoxide (O 2 ) ions have been reported to have an inhibitory effect on SOD and catalase activities, respectively, the authors have suggested that riboflavin deficiency may lead to an overproduction of reactive oxygen species (obviously through a mechanism independent of the glutathione redox cycle) beyond the scavenging ability of SOD and catalase

Siegfried JM, DeMichele MA, Hunt JD, Davis AG, Vohra KP, Pilewski JM

This sensitivity arises from the indole ring of Trp, which is characterized by a relatively large dipole moment both in the ground and excited states it extensively interacts with polar and charged groups in its environment, and whose photophysical properties are affected by surrounding residues, solvent exposure, and molecular motion (Lakowicz, 1983

Effect of Ornithine -Ketoglutarate on intestinal microbiota and serum inflammatory cytokines in dextran sulfate sodium induced colitis