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Furthermore, there may be concerns regarding the long-term safety profile and uncommon adverse effects associated with GLP-1 receptor agonists, which may limit their use in specific patient populations

In type 2 diabetes Phase 2 trials, HbA1c dropped by 1.3%2.0% and the 12mg group lost an average of 16.9% body weight (17.2 kg) over 8 months

Safety data for human use does not exist in peer-reviewed form as of 2026

(138) demonstrated that administration of a single dose short-acting GLP-1RA exenatide increased GH levels, whereas administration of long-acting GLP-1RA liraglutide daily for 21 days elicited increased GH levels with no changes in IGF-I levels in healthy subjects