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Gallbladder disease : Including cholelithiasis and cholecystitis, particularly in those experiencing substantial weight loss Renal impairment : Secondary to dehydration from gastrointestinal side effects Ileus/intestinal obstruction : Post-marketing reports exist with GLP-1 receptor agonists (causality not established)

GIP receptor: Boosts meal-stimulated insulin and can influence fat storage, affecting how the body handles calories