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"Carpal tunnel release: efficacy and recurrence rate after a limited incision release"

As of April 2026, the following clinical realities must be noted: Limited Human Trials: While Phase 1/2 exploratory studies have investigated peptide safety and local administration (e.g., intra-articular for osteoarthritis), large-scale Randomized Controlled Trials (RCTs) confirming systemic efficacy in humans are absent (Dove Medical Press, 2025)

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TLR4 is lower in resistance-trained older women and related to inflammatory cytokines