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In a Phase 2b study in people with type 2 diabetes and obesity over 54 weeks, treatment with cotadutide at doses of 100-300 g daily improved some non-invasive markers of NAFLD such as transaminase levels, the FIB-4 index, fatty liver disease fibrosis score (NFS) and fatty liver index (FLI) but fatty liver disease was not assessed directly with liver biopsy

Retatrutide is not FDA-approved and is available only for research purposes

2024;12 [Google Scholar] 127.Craddock T.J., Hedrick T., De Abreu I.R