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Nevertheless, the immunosuppressive TME remains a major barrier limiting the efficacy and response rates of such therapies

But it may also lower the risk of other diseases, including diabetes

Covariates Data on covariates were obtained using ICD-8 (19771993) and ICD-10 (19932018) codes ( Supplemental Table S2 ), ATC codes (19952018) ( Supplemental Table S3 ), or a combination of both ( Supplemental Table S4 )