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If food becomes less stimulating, other sensory experiences, like fragrance, may feel more salient or rewarding, Stanford said

Among other things, theyre worried about patients having to take them indefinitely to avoid a rebound effect and the potential for sizeable off-label use

The work underscores celastrol's promise as a pharmacological option for combating obesity and its metabolic repercussions, advocating for further investigation into its mechanisms and therapeutic applications [50]