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Owing to its integrated mechanism of action on relevant cell types and the amelioration of OA symptoms, liraglutide could be a potential DMOAD for treating OA

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The homologous cytochrome CYP2A6 of humans in Cyp2a5 mice is expressed in several liver diseases by the induction of toxic chemicals [77], where the levels of mRNA and Cyp2a5, on comparison between knockout NRF-2/ and wild-type mice, proved the increase of NRF-2 and Cyp2a5 in wild-type mice, as well as their interaction by co-immunoprecipitation Cyp controlled by NRF-2 [77]

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doi: 10.1016/0300-483X(93)90092-7

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However, there is no FDA-approved indication for GLP-1 medications in treating rheumatoid arthritis , and any such use would be considered off-label

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