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Brain Res 181 : 151160

The shift from laboratory-scale to industrial-scale production frequently results in variability in vesicle size, lamellarity, encapsulation efficiency, and batch consistency, largely due to the sensitivity of liposome characteristics to process parameters like hydration rate, extrusion pressure, and lipid composition

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Indeed, in vitro studies showed that cells expressing the sst 5 TMD2 mainly respond to cortistatin, whereas those expressing sst 5 TMD4 were exclusively activated by somatostatin and those bearing the sst 5 TMD1 responded to both ligands (Cordoba-Chacon et al., 5 TMD4, while somatostatin activates the sst 5 TMD5 (Duran-Prado et al., Somatostatin in the brain exerts a wide variety of physiological functions besides the initially described inhibitory effect on growth hormone release