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Evidence from TRIUMPH-4 and TRIUMPH-1: Mostly rated as "mild" by participants Rarely led to discontinuation (12%) No progression to serious neurological issues Reversible when medication stopped (in Phase 2 extension) When to Call Your Doctor About Dysesthesia Call if you experience: Severe pain (not just tingling) Progressive worsening despite dose stability Loss of coordination or balance Weakness in hands or feet Symptoms interfering with daily life Likely benign if: Mild tingling only Stable or improving over time No pain or weakness Managing Nausea: The Most Common Side Effect Why GLP-1 Medications Cause Nausea GLP-1 slows gastric emptying food stays in stomach longer Longer gastric residence feeling of fullness (desired!) or nausea (not desired) Brain signaling changes nausea sensation Good news: This is the SAME mechanism producing weight loss
Archived from the original on 9 October 2019
The trial also showed that the combination produced dose-dependent, sustained weight loss without concerning additional adverse effects the side effect profile was broadly consistent with what would be expected from each individual agent
Spending on savory snacks dropped by about 10%, with similarly large decreases in sweets, baked goods, and cookies
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