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GSTM1 and GSTP1, but not GSTT1 genetic polymorphisms are associated with chronic myeloid leukemia risk and treatment response

Red flags to watch for Certain indicators suggest a compounding pharmacy may not meet quality standards: No FDA registration or refusal to provide registration number No certificates of analysis available Prices dramatically lower than competitors without explanation No physician oversight required for obtaining prescriptions Claims that compounded products are "the same as" FDA-approved versions Inability or unwillingness to describe quality control procedures History of FDA Warning Letters (more serious than Form 483s) No stability testing data for their specific formulations Avoiding common mistakes when selecting pharmaceutical products starts with understanding that the cheapest option is rarely the safest option, and the most expensive option is not automatically the best

Response: In the CY 2026 PFS proposed rule (90 FR 32678), we stated that we believe it would be contrary to the public interest to apply the proposed removal of the health equity adjustment applied to an ACO's quality score prospectively only