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These metabolic alterations may be closely linked to the pathophysiological mechanisms underlying depression [393, 394]

Taking it with a heavy meal compounds the problem

* Correspondence: Evgeny Ruchko, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The safest and most ethical approach is to guide patients toward FDA-approved treatments and reinforce why unapproved compounds are not appropriate for clinical use