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Diet: A diet high in trans fat or saturated fat leads to increased cholesterol levels

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Moreover, there are several paradigmatic conditions such as Down syndrome, phenylketonuria, and various lipidoses (Scriver et al., 1989) where the metabolic abnormalities are expressed in both neural and peripheral tissues, but the functional consequences are most profound in the central nervous system (CNS)

Ensuring adequate availability of all essential amino acids is therefore critical for leucine-mediated stimulation of muscle protein synthesis and optimal metabolic outcomes (5254)