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For people with genetic predispositions toward higher appetite drive (such as variants in the GLP1R or MC4R genes), this rebound can feel especially intense because their baseline hunger regulation is naturally more aggressive

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Over-the-counter remedies such as simeticone (for gas and bloating) or loperamide (for diarrhoea) can provide symptomatic relief, though patients should consult their GP or pharmacist before regular use