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Blocking the TLR2 pathway inhibits pro-inflammatory cytokines (IL-6, IL-8, and IL-1) and promotes the expression of tight junction proteins, hence restoring the epidermal barrier in AD ( 5 The role of cytokines and adipokines in obesity and AD Analysis of bodies of obese individuals has revealed the presence of metabolic abnormalities, oxidative stress, mitochondrial dysfunction, impaired immune function, and chronic low-grade inflammation ( 5.1 TNF- TNF- is a cytokine that plays a role in inflammation and immune responses ( 5.2 IL-6 Research on the relationship between IL-6 levels in obesity and AD is limited.IL-6 regulates autoimmune and chronic inflammatory diseases

Randomization took place after a 6-week run-in period consisting of a 3-week forced metformin and glimepiride titration period followed by a maintenance period of another 3 weeks

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