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The effectiveness of these administration strategies depends on various factors, including bioavailability, drug formulation, gastrointestinal conditions, and systemic distribution, which, if not optimized, could compromise therapeutic outcomes and limit the antibiotics efficacy against targeted infections (McCarthy and Avent, 2020

In addition, BT2 alleviates neurobehavioral disorders in mice after I/R injury, with effects similar to those of Fer-1

PLoS ONE 15 , e0228212 (2020)

Feeding behavior is itself under circadian control, with appetite, digestion, and metabolic hormone release peaking at certain times, but reciprocally, the timing of food intake also feeds back onto the clock as a zeitgeber for peripheral organs