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New Insights into the Structure and Function of Class B1 GPCRs

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The intrinsic stimuli include apoptosis-including genes like p53, Bax and Fas, but also Bcl-2 and c-kit genes which act as apoptosis suppressors [100], while extrinsic stimuli consist of varicocele, infection, heat stress, environmental toxins, advanced male age lifestyle factors, ionizing and nonionizing radiations, defective protamination and idiopathic causes [101, 102]

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