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All kidney samples from the F344-Lewis kidney transplantation models were qualified for sequencing analysis, comprising 6 samples from the syngeneic group, 7 samples from vehicle-treated group, and 8 samples from TB001-treated group

Most patients begin to notice weight loss within the first 4-8 weeks of treatment, with continued loss over 12-18 months as the dose is titrated upward

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This high dosage is specifically supported by long-term clinical trials demonstrating its efficacy in raising cellular stores over time