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Developing microbiome-targeting methodologies by understanding the role of gut microbiome in response to drugs can improve drug efficiency and reduce adverse drug effects ( Gut microbiota composition changes due to metformin Metformin is increasingly recognised for its role in the gut, including modifications to the microbiome which might account for some of the drugs therapeutic efficacy and side effects ( Escherichia, Romboutsia, Intestinibacter, and Clostridium )

This typical reaction will fade with time

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