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These results are consistent with SURPASS2, a 40week, openlabel, phase 3 trial in a cohort of patients with metformintreated T2D in which onceweekly tirzepatide (5, 10, or 15 mg) was noninferior and superior to semaglutide 1 mg for HbA1c reduction and produced substantially greater, dosedependent weight loss

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Retatrutides triple receptor activation offers comprehensive metabolic benefits with superior weight loss efficacy, while Wegovys high-dose GLP-1 receptor targeting provides substantial weight loss with established safety profiles and regulatory approval

Cons: Needles and injections: Even with thin needles, many patients dislike self-injecting