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In contrast, Syk kinases are activated through the interaction of their tandem Src homology 2 domains with ITAM domains, 374 primarily regulating the activation of neutrophils by ICs through FcR, 375 essential against various pathogens including bacteria and fungi

Experimental receptor binding assays indicate that Cagrilintide can activate both amylin receptor subtypes and the calcitonin receptor itself, producing measurable signaling responses in cellular assay systems

doi: 10.1016/S0022-2275(20)31973-8 189 ECHA