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Mice with inactivation of the urokinase plasminogen activator receptor (uPAR) gene, a key component of the HGF activation (Powell et al., 2001)

Functional failure takes the degenerated IVD to a state of disc pathology that has various phenotypes: the most common forms are disc herniation, mechanical instability, spinal stenosis, degenerative spondylolisthesis and degenerative scoliosis

It was found that heat shock protein beta-1 (HSPB1) can further reduce intracellular iron concentrations by inhibiting TRF1 expression, and so overexpressed HSPB1 can significantly inhibit ferroptosis 27

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