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A validation study on 51 patients receiving anti-PD-1 therapy alone or in combination (NCT02644369) (235), found no association between choline levels and changes in absolute neutrophil count (ANC), lymphocytes, and neutrophil-to-lymphocyte ratio (NLR) (235)

If affordable, basal insulin analogue formulations are preferred to NPH insulin because of their reduced risk of hypoglycaemia, particularly nocturnal hypoglycaemia, when titrated to the same fasting glucose target [327]

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The report also noted that a large Phase IIb trial (ZUPREME-1) is underway with enrolment expected to be completed in the first half of 2025 and that a second Phase IIb trial (ZUPREME-2) is planned to evaluate petrelintide in individuals with type 2 diabetes