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In guinea pig uterine models treated with combined estrogen and progesterone, elevated OS markers8-isoprostane and 8-hydroxy-2-deoxyguanosine (8-OHdG)occurred concurrently with abnormal vascular morphology (87)

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Vitamin C helps lighten spots and stimulate collagen for firming the skin

Therefore, altered gut microbiota play a crucial role in RE development, suggesting the need to further identify key beneficial or pathogenic bacteria