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Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers

Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), people following vegan or strict vegetarian diets (as B12 is naturally found almost exclusively in animal products), individuals with pernicious anaemia or other malabsorption conditions, those taking certain medications such as metformin or proton pump inhibitors long-term, and people with significant nitrous oxide exposure (including recreational use), which can inactivate B12 in the body

Aim for 80 to 100 grams of protein daily, distributed across 4 to 6 meals

Dose-Response Patterns Phase 1/2 trials tested CJC-1295 with DAC at single doses ranging from 30-250 mcg/kg (PMID 16352683)