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Manufactured for and marketed by: Karyopharm Therapeutics Inc., 85 Wells Avenue, Newton, MA, 02459

Site and personnel eligibility The Department of Pediatrics at Kyungpook National University Hospital (KNUH) served as the single study site for this investigation, a tertiary care center with clinical laboratory accreditation and capabilities for pediatric neurodevelopmental assessments, phlebotomy, and secure biobanking

The final measurement at the end of this step reflects the total content of GSH (free GSH + GSSG) in the samples, to calculate the GSSG content, the free GSH content must be subtracted from the total GSH content

In the retina, GPER activation can promote the survival of retinal neurons and enhance the function of photoreceptors, which is crucial for maintaining a normal visual capacity [114]