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The factors that lead to depletion of glutathione includes natural ageing process, or the external stressors that include chronic exposure to chemical toxins, cadmium exposure, alcohol use, smoking, pollution, strenuous aerobic activities, dietary factors, ultraviolet (UV) radiation exposure, tissue injury as from burns, ischemia, septic shock, surgery, drugs (such as acetaminophen and adriamycin)

Symptomatic treatment with antiepileptic drugs carries risks of adverse effects and drug interactions

A melatonin supplement , taken at night to help you sleep or for jet lag, may interfere with hormonal birth control, but theres not enough scientific evidence to know for sure