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If the lack of a period is due to too much estrogen compared to other hormones, as is the case with PCOS or excess weight, then there is the added risk of having abnormal cells develop in the uterus, Dr
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These conditions of loading go beyond the capacity of the endogenous antioxidant defense system, with clear depletion of glutathione activity, which is overwhelmed by massive generation of ROS from cellular Fe 2+ engaged in Fenton reactions/HaberWeiss reactions 2,3
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