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Yakunin E, Kisos H, Kulik W, Grigoletto J, Wanders RJ, Sharon R

Protein Stability During Purification Challenge : Proteins, including GST-tagged ones, can be prone to degradation or loss of activity during the purification process, particularly when exposed to harsh conditions or prolonged processing times

doi: 10.1620/tjem.226.251 177 TsaiWCYangYM

"While glutathione is a powerful antioxidant and theoretically could reduce oxidative stress in melanocytes, there is no robust clinical data showing that increasing dietary or supplemental glutathione can reliably prevent or reverse gray hair in humans." The body's regulation of hair pigmentation is complex, he added, and once melanocytes lose their ability to produce pigment, antioxidants alone are unlikely to restore it