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These investigations followed reports of individuals taking semaglutide and similar drugs exhibiting such behavior

The application of these models in toxico-metabolomic research can help identify potential drug toxicity issues early in drug development process, allowing for timely intervention (Figure 7)

Exercise counteracts this process by promoting the conversion of kynurenine into kynurenic acid, a neuroprotective metabolite, thereby shifting the pathway away from neurotoxicity [257, 258]