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Strategies to minimize gastrointestinal discomfort include gradual dose titration, administration with meals to reduce nausea, and lifestyle modifications such as dietary adjustments and increased fluid intake

Seek urgent medical attention (call 999 or go to A&E) if you experience: Chest pain or tightness, particularly if radiating to the arm, jaw, or back Sudden shortness of breath at rest or with minimal exertion Palpitations accompanied by dizziness, fainting, or loss of consciousness Rapid or irregular heartbeat that does not resolve within a few minutes Sudden swelling of the legs or ankles combined with breathlessness (possible signs of heart failure) If you need urgent medical advice and it is not life-threatening, call NHS 111 or use 111 online

95% CI 0.93, 1.01)

Indigestion or heartburn is another common complaint, as the digestion of fats becomes less efficient