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doi: 10.3748/wjg.v16.i11.1304 21

Some patients may require dose escalation to 2.0 mg for additional therapeutic benefit

Bromodomain protein BRD4 is a transcriptional repressor of autophagy and lysosomal function

For example, CKD patients have been found to exhibit increased intestinal permeability, reduced gut motility, bacterial overgrowth, bacterial translocation, and intestinal inflammation (Cosola et al., 2021