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Diabetic Retinopathy Complications in Patients with a History of Diabetic Retinopathy: Rapid improvement of glucose control has been associated with temporary worsening of diabetic retinopathy

Participants with obesity (body mass index (BMI) 30 kg/m) and moderate-to-severe KOA pain experienced significantly greater reductions in body weight and OA-related pain with weekly semaglutide injections compared to placebo [52]

In the longer term, you could combine a GLP-1 with medication preventing muscle loss, or even more fundamentally, design the weight loss medications to be directed fully to adipose tissue while minimizing muscle loss

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