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However, their therapeutic utility has been limited by issues such as low solubility, short biological half-life, high lipophilicity, dose-dependent toxicity, and nonspecific accumulation in the body [333]

Rosenstock J et al

The author JR-K declared that they were an editorial board member of Frontiers at the time of submission

One 2004 study reported that epithalamin influenced circadian melatonin patterns in healthy elderly subjects, particularly among those with lower baseline pineal activity