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The latest GLP-1 coverage expansion and AI initiatives support the existing narrative but do not materially change these near term drivers

Because all included studies were observational cohorts, results were interpreted cautiously

It works by targeting two hormones, GIP and GLP-1 , which help the body manage blood sugar, reduce hunger, and increase feelings of fullness

In global terms, hypothalamic pathways involved in autophagy, neurotransmitter release, cytoskeletal remodeling (RHO GTPases signaling), vesicle-mediated transport and intracellular signaling (PI3K/AKT activation) were upregulated in PWA mice treated with GLP1/E, while pathways related with vesicle transport, oxidative stress, DNA repair, metabolism and immune system were downregulated by GLP1/E treatment (Fig