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By mimicking the actions of the GLP-1 hormone, semaglutide and its counterparts, liraglutide, and dulaglutide, work to lower blood glucose in patients with type 2 diabetes

As digestion progresses and nutrients move through the small intestine, direct contact between nutrients and L-cells triggers the main phase of GLP-1 secretion

This endothelial dysfunction decreases the potent vasodilator nitric oxide (NO) in endothelial and vascular muscle smooth cells, increases the levels of vasoconstrictors such as endothelin-1 [13], and creates a hypercoagulable state by activating platelet aggregation and inhibiting fibrinolysis [14]

This impacts aspiration risk and perioperative glycemic management