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During the remodeling phase, continuous collagen formation and breakdown occur and are principally kept in balance by the activity of matrix metalloproteinases ( Pathophysiology of diabetic wound healing Open wounds that do not heal are referred to as non-healing wounds

doi: 10.3945/ajcn.2010.28674J 34 SchwarzMMeyerCELserALossowKHacklerJOttCet al

Abstract The paradigm of one drug against multiple targets, known as unimolecular polypharmacology, offers the potential to improve efficacy while overcoming some adverse events associated with the treatment

Putting the Numbers in Context The beta coefficients from this meta-analysis represent the independent effect of each treatment after controlling for confounding variables