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People with MCAS often report the same sensitivity, so it may mean that we experience effects at lower doses that more normal immune systems may not

Comment: A few commenters recommended CMS keep the requirement to encode the estimated allowed amount in the MRF instead of replacing it with the median allowed amount and adding the 10th and 90th percentile allowed amounts, indicating they believe that given the volume and complexity of the MRFs, the average would provide a more accurate estimate of what a hospital has historically received for that item or service

While the simulations are confined by these assumptions, it is worth noting that redox cycling is governed by thermodynamics, which according to the reduction potential of doxorubicin, are favourable with respect to the formation of superoxide should a semiquinone radical species be present 3