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Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport J Neurochem 2000

This is true across almost all practice sizes, except for solo practitioners

Then, in the Medicare Payment Advisory Commission's (MedPAC) January 2007 Report to Congress, Impact of Changes in Medicare Payments for Part B Drugs, [141] they discussed the issue of allocation of bundled price concessions for purposes of calculating the manufacturer's ASP, noting that some manufacturers offer provider discounts for one of their products contingent on purchases of one or more other products. In light of MedPAC's recommendation that CMS address the ASP reporting requirements for bundled products and our discussion of bundled price concessions in the CY 2007 PFS rulemaking, we stated in the CY 2008 PFS proposed rule (72 FR 38150 through 38151) that we believe specific guidance in the ASP context is warranted to ensure consistency in ASP reporting across manufacturers and to enhance the accuracy of the ASP payment system

Among other things, they wrote, this could lead to confirmation bias