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Further, for poorly water-soluble drugs and biopharmaceuticals, such as proteins and peptides, powder formulations facilitate the formulation of larger drug doses by co-formulating using excipients that act as bulking agents (water-soluble fillers: lactose, trehalose, mannitol, and sorbitol

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Cloudiness, yellow discoloration, or visible particles indicate advanced aggregationby the time degradation is visible, the peptide has been compromised for days and should be discarded immediately

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