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Phase 3 TRIUMPH-4 trial The most recent Phase 3 results, announced in December 2025, tested retatrutide in people with obesity and knee osteoarthritis

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The tirzepatide dose can then be increased every 4 weeks based on efficacy and tolerability

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Pharmacokinetics: Assessment of pharmacokinetic behavior in controlled research environments

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2024, Diabetes Obes Metab 26(3):911-923, which confirmed similar weight loss magnitudes)

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